Thresholds 6
Latest published thresholds page.
Thresholds
Threshold comparison pages
Published threshold pages available for quick review.
Welcome to the CliniSearch Clinical Thresholds Library. This resource provides a centralised repository of published threshold comparison pages, designed to support clinicians in making informed decisions based on the latest evidence and guidelines. Thresholds are critical values or cut-off points used in clinical practice to guide diagnosis, treatment initiation, monitoring, and referral. Variations can exist between different national guidelines, and this library aims to highlight these differences for clarity and improved patient care.
Each threshold page is meticulously compiled, referencing authoritative sources such as NICE (National Institute for Health and Care Excellence), SIGN (Scottish Intercollegiate Guidelines Network), and other relevant UK health bodies. The comparisons are presented in a clear, tabular format to facilitate quick reference at the point of care. It is essential to remember that these thresholds are aids to clinical judgement and must be applied within the context of the individual patient and local healthcare policies.
Understanding Clinical Thresholds
Clinical thresholds are fundamental to evidence-based medicine. They represent the point at which the probability of a disease is considered high enough to warrant diagnostic testing, or the benefit of a treatment is judged to outweigh the risks. For example, a HbA1c threshold might determine a diagnosis of diabetes, while a cholesterol level might guide the initiation of statin therapy. These values are not arbitrary; they are derived from large-scale clinical trials, epidemiological studies, and expert consensus to maximise patient outcomes and the efficient use of healthcare resources.
However, guidelines can be updated as new evidence emerges, and different organisations may interpret evidence slightly differently, leading to variations in recommended thresholds. This library helps clinicians stay abreast of these differences, ensuring that decision-making is aligned with the most current and comprehensive information available. It is particularly useful for healthcare professionals working across different UK nations or those reviewing patients whose care may have been initiated under a different guideline set.
How to Use This Library
The pages within this library are organised numerically, with the most recent publication featured prominently. To find a specific clinical area, browse the list of available threshold pages below. Each page provides a direct comparison of thresholds from key UK guidelines for a particular condition or parameter. The tables typically include columns for the parameter name, the recommending body (e.g., NICE, SIGN), the specific threshold value, and any relevant notes on the context or population for which the threshold applies.
When using these resources, clinicians should:
- Verify the Source: Always check the publication date and ensure you are referencing the most current version of a guideline. Links to the original source documents are provided where possible.
- Apply Clinical Judgement: Thresholds are guides, not rules. Patient factors such as age, comorbidities, and preferences must be integrated into the final clinical decision.
- Follow Local Policy: NHS Trusts and Health Boards may have local adaptations of national guidelines. Always adhere to your organisation's specific protocols and policies.
This library is a dynamic resource, and new comparison pages will be added as guidelines are updated or new topics are identified as being of high clinical relevance.
Available Threshold Pages
Cardiovascular Risk Thresholds
Comparison of QRISK2/3 thresholds for primary prevention of cardiovascular disease as recommended by NICE, SIGN, and other bodies.
Diabetes Diagnosis and Management
HbA1c, fasting glucose, and other biochemical thresholds for diagnosing and monitoring diabetes mellitus.
Renal Function and CKD Staging
eGFR and ACR thresholds for chronic kidney disease staging and referral criteria.
Antibiotic Prophylaxis
Thresholds for initiating antibiotic prophylaxis in various clinical scenarios, including infective endocarditis and surgical procedures.
Haematological Parameters
Reference thresholds for full blood count parameters and coagulation studies across different patient populations.
Clinical Safety and Updates
CliniSearch is committed to clinical safety. The information presented in this thresholds library is compiled with care from reputable sources. However, it is imperative to note that CliniSearch is not a medical device. The responsibility for the safe and effective application of this information rests solely with the qualified healthcare professional. We strongly recommend that users cross-reference any thresholds with the original, full-text guideline documents before making clinical decisions.
Our team monitors guideline updates from major UK health organisations. When a significant change to a threshold is published, the corresponding comparison page will be updated, and a new version will be released. The version number of each page is displayed for clarity. For detailed information on our clinical safety processes, please visit our Clinical Safety & Assurance page.