Clinical guidelines in primary care

Find GP-ready guidance with NICE links and update alerts.

Covers core GP pathways, prescribing, referral thresholds, and keeping guidance current.

Last updated: 15 Dec 2025

Guidelines commonly used by GPs

Primary care relies on NICE, SIGN, BTS, and local formularies to keep GP decisions safe, consistent, and defensible.

Applies to GP and multidisciplinary primary care teams across the UK.

GPs in the UK rely on a robust framework of national clinical guidelines to standardise care, promote best practice, and ensure patient safety, with key guidance often sourced from the National Institute for Health and Care Excellence (NICE), which provides comprehensive, evidence-based recommendations covering a vast range of conditions encountered in primary care, from the management of common chronic diseases like hypertension, type 2 diabetes, and asthma to mental health conditions such as depression and anxiety, alongside guidance on cancer recognition and referral, cardiovascular disease prevention, and antimicrobial stewardship. The Scottish Intercollegiate Guidelines Network (SIGN) offers similarly authoritative guidance, which is widely utilised by GPs across Scotland, while other crucial resources include the British Thoracic Society (BTS) guidelines for respiratory diseases, the British National Formulary (BNF) for prescribing, and the UK Health Security Agency (UKHSA) guidelines for immunisation and infectious disease management.

NICE CKS and primary care tools

In primary care, clinical guidelines are essential tools that synthesise the best available evidence into practical recommendations to support clinicians in delivering consistent, high-quality care, with the National Institute for Health and Care Excellence (NICE) Clinical Knowledge Summaries (CKS) being a particularly valuable resource designed specifically for the primary care setting, offering succinct, evidence-based summaries on a wide range of common conditions encountered in general practice, which are structured to facilitate quick access to key information such as diagnosis, management options, prescribing advice, and referral criteria, thereby aiding in clinical decision-making during time-pressured consultations.

The development of these guidelines involves a rigorous process of evidence review and expert consensus to ensure they are both robust and applicable to the UK healthcare context, taking into account the realities of working within the National Health Service (NHS), including considerations of cost-effectiveness and resource availability, which is crucial for prioritising interventions in a system with finite resources. Primary care clinicians must also be adept at navigating and critically appraising guidelines from various sources beyond NICE CKS, such as those from specialist societies or other national bodies, while recognising that guidelines are not a substitute for clinical judgement but rather a framework that must be adapted to individual patient circumstances, preferences, and comorbidities.

Managing long-term conditions

Effective management of long-term conditions in primary care requires a proactive, patient-centred approach that integrates evidence-based medicine with personalised care planning, underpinned by robust clinical monitoring and multidisciplinary teamwork to optimise health outcomes and quality of life for patients living with chronic illness. The foundation of care begins with establishing an accurate diagnosis and a comprehensive baseline assessment, which should encompass not only the clinical parameters of the condition but also a holistic evaluation of the patient's physical, psychological, and social needs, their health beliefs, and their capacity for self-management.

Regular structured reviews are essential, with the frequency and focus tailored to the individual's condition stability, risk factors, and personal circumstances, ensuring these consultations move beyond simple monitoring to include agenda-setting agreed with the patient, proactive management of cardiovascular and other relevant risk factors, medication review including assessment of adherence and potential side effects, and opportunistic health promotion such as smoking cessation support and advice on physical activity.

Keeping guidelines up to date

Keeping clinical guidelines up to date in primary care is a continuous and essential process to ensure patient safety and the delivery of evidence-based care, requiring clinicians to adopt a systematic and practical approach to managing the constant influx of new evidence and revised recommendations. The responsibility for staying current falls on individual practitioners and the wider practice team, with effective strategies including establishing a designated lead, often a GP or a practice pharmacist, who is responsible for monitoring key sources of updates.

Integrating updates into clinical practice involves more than just passive awareness; it requires active dissemination and implementation, which can be achieved through scheduled practice meetings where new or significantly changed guidelines are discussed, with a focus on summarising the key changes, comparing them to previous recommendations, and identifying the practical implications for the practice's patient population, workflows, and prescribing habits. To ensure adherence and identify any barriers to implementation, practices should consider targeted clinical audits a few months after a significant guideline change.

Frequently asked questions

Which guidelines are core for primary care?

Common long-term conditions (HTN, diabetes, asthma), mental health, and antimicrobial prescribing plus local pathways.

How to keep guidance current in practice?

Use local formulary/ICB updates, NICE email alerts, and EHR decision support if available.

When to refer to secondary care?

When red flags, diagnostic uncertainty, or specialist interventions are required; follow local pathways.

How often to review long-term conditions?

Per condition guidance, typically every 6–12 months or sooner for unstable patients.